منابع مشابه
Methoxyflurane nephrotoxicity--a review and a case report.
METr~OX~LtraANE ( 1,1 difluoro, 2,2 diehloro ethyl methyl ether) was first investigated as an anaesthetic in dogs by Van Poznak and Artusio, and, subsequently in 1960, Artusio e t al . ' reported on the clinical use in man. It is estimated that since that time, approximately 15 million methoxyflurane anaesthetics have been administered. The clinical advantages of its u s e have been found in it...
متن کاملMethoxyflurane nephropathy.
Investigations of methoxyflurane-induced nephrotoxicity in man have been extensively aided by the use of an animal model. To be of value the animal model must share similar metabolic pathways with man and have the same clinical manifestations of the diseases process. The Fischer 344 rat appears to meet these criteria. The predominant factors in the production of methoxyflurane nephrotoxicity ap...
متن کاملMethoxyflurane and renal function.
The results of a prospective study comparing renal function after anaesthesia using methoxyflurane, halothane or phenoperidine indicate that the use of methoxyflurane is associated with a significant rise in serum uric acid, probably caused by transient distal tubular dysfunction. Reasons are presented to suggest that the rise in serum uric acid is related to urinary fluoride derived from the b...
متن کاملNew insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.
BACKGROUND Methoxyflurane nephrotoxicity results from biotransformation; inorganic fluoride is a toxic metabolite. Concern exists about potential renal toxicity from volatile anesthetic defluorination, but many anesthetics increase fluoride concentrations without consequence. Methoxyflurane is metabolized by both dechlorination to methoxydifluoroacetic acid (MDFA, which may degrade to fluoride)...
متن کاملMethoxyflurane analgesia for burns dressings.
THE terms 'burns dressing' and 'analgesia', as they are understood in the Mclndoe Burns Unit at East Grinstead, will first be defined. Methoxyflurane as an analgesic for burns dressings will then be discussed. The term 'burns dressing' may mean: (1) Debridement and cleansing of the burn wound on admission, together with intravenous cannulation and urethral catheterization. (2) Removal of old dr...
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ژورنال
عنوان ژورنال: BMJ
سال: 1974
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5929.524-c